Nitrogen deprivation in Fusarium oxysporum promotes mycotoxin production via intermediates in the Krebs cycle and unreported methylmalonyl-CoA mutase activity.
Identifieur interne : 000D69 ( Main/Exploration ); précédent : 000D68; suivant : 000D70Nitrogen deprivation in Fusarium oxysporum promotes mycotoxin production via intermediates in the Krebs cycle and unreported methylmalonyl-CoA mutase activity.
Auteurs : A V Karpe [Australie] ; M S Dunn [Australie] ; M C Taylor [Australie] ; T. Nguyen [Australie] ; C. Ong [Australie] ; T. Karla [Australie] ; S. Rockman [Australie] ; D J Beale [Australie]Source :
- Metabolomics : Official journal of the Metabolomic Society [ 1573-3890 ] ; 2018.
Descripteurs français
- KwdFr :
- Azote (déficit), Chromatographie gazeuse-spectrométrie de masse (MeSH), Cycle citrique (MeSH), Fusarium (croissance et développement), Fusarium (métabolisme), Methylmalonyl-coA mutase (métabolisme), Mycotoxines (analyse), Mycotoxines (métabolisme), Métabolome (MeSH), Voies et réseaux métaboliques (MeSH).
- MESH :
- analyse : Mycotoxines.
- croissance et développement : Fusarium.
- déficit : Azote.
- métabolisme : Fusarium, Methylmalonyl-coA mutase, Mycotoxines.
- Chromatographie gazeuse-spectrométrie de masse, Cycle citrique, Métabolome, Voies et réseaux métaboliques.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Mycotoxins.
- chemical , deficiency : Nitrogen.
- chemical , metabolism : Methylmalonyl-CoA Mutase, Mycotoxins.
- growth & development : Fusarium.
- metabolism : Fusarium.
- Citric Acid Cycle, Gas Chromatography-Mass Spectrometry, Metabolic Networks and Pathways, Metabolome.
Abstract
INTRODUCTION
Fusarium oxysporum has a high affinity for lignin and cellulose-based substrates and is known to grow in a wide range of environments. It is these properties and its ability to produce mycotoxins that have contributed to its pathogenicity in cereal crops that can affect human and animal health when ingested.
OBJECTIVES
Identify the mechanisms of mycotoxin production and map the functional output of F. oxysporum under varying growth conditions.
METHODS
Liquid and gas-based chromatography coupled with mass spectrometry was used to identify and map the untargeted metabolic pathway of F. oxysporum grown using nitrogen limited and organic/inorganic nitrogen supplemented media.
RESULTS
Over 1300 metabolites were identified, relating to 42 metabolic pathways. Of these, 520 metabolites merged at pyruvate (glycolysis), succinate (Krebs cycle) and aspartate-glutamate metabolic pathways. CoA depletion at the growth stage triggered the initiation of fatty acid and branched amino acid degradation. This in turn activated propionyl CoA carnitine acetyltransferase enzymes, resulting in nitrogen preservation (urea, putrescine and organic acids end-products). CoA then transferred into the TCA cycle via previously unreported β-alanine and propionyl CoA metabolic pathways, the latter likely being a novel methylmalonyl-CoA mutase activity for F. oxysporum.
CONCLUSIONS
The lower supplementation of inorganic nitrogen compounds (≤ 50 mM) and the elimination of nitrates/organic nitrogen sources resulted in TCA autophagy events that boosted mycotoxin-based metabolism and decreased overall F. oxysporum growth. Such knowledge of functional mycotoxin production can be used to supplement agricultural crops and reduce the risk of mycotoxin contamination in human and animal food supplies.
DOI: 10.1007/s11306-018-1459-0
PubMed: 30830469
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Karla</name><affiliation wicri:level="1"><nlm:affiliation>Technical Development, Seqirus, 63 Poplar Road, Parkville, VIC, 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Technical Development, Seqirus, 63 Poplar Road, Parkville, VIC, 3052</wicri:regionArea><wicri:noRegion>3052</wicri:noRegion></affiliation></author><author><name sortKey="Rockman, S" sort="Rockman, S" uniqKey="Rockman S" first="S" last="Rockman">S. 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Nguyen</name><affiliation wicri:level="1"><nlm:affiliation>Technical Development, Seqirus, 63 Poplar Road, Parkville, VIC, 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Technical Development, Seqirus, 63 Poplar Road, Parkville, VIC, 3052</wicri:regionArea><wicri:noRegion>3052</wicri:noRegion></affiliation></author><author><name sortKey="Ong, C" sort="Ong, C" uniqKey="Ong C" first="C" last="Ong">C. Ong</name><affiliation wicri:level="1"><nlm:affiliation>Technical Development, Seqirus, 63 Poplar Road, Parkville, VIC, 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Technical Development, Seqirus, 63 Poplar Road, Parkville, VIC, 3052</wicri:regionArea><wicri:noRegion>3052</wicri:noRegion></affiliation></author><author><name sortKey="Karla, T" sort="Karla, T" uniqKey="Karla T" first="T" last="Karla">T. Karla</name><affiliation wicri:level="1"><nlm:affiliation>Technical Development, Seqirus, 63 Poplar Road, Parkville, VIC, 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Technical Development, Seqirus, 63 Poplar Road, Parkville, VIC, 3052</wicri:regionArea><wicri:noRegion>3052</wicri:noRegion></affiliation></author><author><name sortKey="Rockman, S" sort="Rockman, S" uniqKey="Rockman S" first="S" last="Rockman">S. Rockman</name><affiliation wicri:level="1"><nlm:affiliation>Technical Development, Seqirus, 63 Poplar Road, Parkville, VIC, 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Technical Development, Seqirus, 63 Poplar Road, Parkville, VIC, 3052</wicri:regionArea><wicri:noRegion>3052</wicri:noRegion></affiliation></author><author><name sortKey="Beale, D J" sort="Beale, D J" uniqKey="Beale D" first="D J" last="Beale">D J Beale</name><affiliation wicri:level="1"><nlm:affiliation>Land & Water, CSIRO, Ecosciences Precinct, Dutton Park, QLD, 4102, Australia. david.beale@csiro.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Land & Water, CSIRO, Ecosciences Precinct, Dutton Park, QLD, 4102</wicri:regionArea><wicri:noRegion>4102</wicri:noRegion></affiliation></author></analytic><series><title level="j">Metabolomics : Official journal of the Metabolomic Society</title><idno type="eISSN">1573-3890</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Citric Acid Cycle (MeSH)</term><term>Fusarium (growth & development)</term><term>Fusarium (metabolism)</term><term>Gas Chromatography-Mass Spectrometry (MeSH)</term><term>Metabolic Networks and Pathways (MeSH)</term><term>Metabolome (MeSH)</term><term>Methylmalonyl-CoA Mutase (metabolism)</term><term>Mycotoxins (analysis)</term><term>Mycotoxins (metabolism)</term><term>Nitrogen (deficiency)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Azote (déficit)</term><term>Chromatographie gazeuse-spectrométrie de masse (MeSH)</term><term>Cycle citrique (MeSH)</term><term>Fusarium (croissance et développement)</term><term>Fusarium (métabolisme)</term><term>Methylmalonyl-coA mutase (métabolisme)</term><term>Mycotoxines (analyse)</term><term>Mycotoxines (métabolisme)</term><term>Métabolome (MeSH)</term><term>Voies et réseaux métaboliques (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Mycotoxins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Nitrogen</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Methylmalonyl-CoA Mutase</term><term>Mycotoxins</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Mycotoxines</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Fusarium</term></keywords><keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Azote</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Fusarium</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Fusarium</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Fusarium</term><term>Methylmalonyl-coA mutase</term><term>Mycotoxines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Citric Acid Cycle</term><term>Gas Chromatography-Mass Spectrometry</term><term>Metabolic Networks and Pathways</term><term>Metabolome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Chromatographie gazeuse-spectrométrie de masse</term><term>Cycle citrique</term><term>Métabolome</term><term>Voies et réseaux métaboliques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b></p><p>Fusarium oxysporum has a high affinity for lignin and cellulose-based substrates and is known to grow in a wide range of environments. It is these properties and its ability to produce mycotoxins that have contributed to its pathogenicity in cereal crops that can affect human and animal health when ingested.</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>Identify the mechanisms of mycotoxin production and map the functional output of F. oxysporum under varying growth conditions.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Liquid and gas-based chromatography coupled with mass spectrometry was used to identify and map the untargeted metabolic pathway of F. oxysporum grown using nitrogen limited and organic/inorganic nitrogen supplemented media.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Over 1300 metabolites were identified, relating to 42 metabolic pathways. Of these, 520 metabolites merged at pyruvate (glycolysis), succinate (Krebs cycle) and aspartate-glutamate metabolic pathways. CoA depletion at the growth stage triggered the initiation of fatty acid and branched amino acid degradation. This in turn activated propionyl CoA carnitine acetyltransferase enzymes, resulting in nitrogen preservation (urea, putrescine and organic acids end-products). CoA then transferred into the TCA cycle via previously unreported β-alanine and propionyl CoA metabolic pathways, the latter likely being a novel methylmalonyl-CoA mutase activity for F. oxysporum.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>The lower supplementation of inorganic nitrogen compounds (≤ 50 mM) and the elimination of nitrates/organic nitrogen sources resulted in TCA autophagy events that boosted mycotoxin-based metabolism and decreased overall F. oxysporum growth. Such knowledge of functional mycotoxin production can be used to supplement agricultural crops and reduce the risk of mycotoxin contamination in human and animal food supplies.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30830469</PMID><DateCompleted><Year>2019</Year><Month>09</Month><Day>19</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>09</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1573-3890</ISSN><JournalIssue CitedMedium="Internet"><Volume>14</Volume><Issue>12</Issue><PubDate><Year>2018</Year><Month>12</Month><Day>11</Day></PubDate></JournalIssue><Title>Metabolomics : Official journal of the Metabolomic Society</Title><ISOAbbreviation>Metabolomics</ISOAbbreviation></Journal><ArticleTitle>Nitrogen deprivation in Fusarium oxysporum promotes mycotoxin production via intermediates in the Krebs cycle and unreported methylmalonyl-CoA mutase activity.</ArticleTitle><Pagination><MedlinePgn>160</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s11306-018-1459-0</ELocationID><Abstract><AbstractText Label="INTRODUCTION">Fusarium oxysporum has a high affinity for lignin and cellulose-based substrates and is known to grow in a wide range of environments. It is these properties and its ability to produce mycotoxins that have contributed to its pathogenicity in cereal crops that can affect human and animal health when ingested.</AbstractText><AbstractText Label="OBJECTIVES">Identify the mechanisms of mycotoxin production and map the functional output of F. oxysporum under varying growth conditions.</AbstractText><AbstractText Label="METHODS">Liquid and gas-based chromatography coupled with mass spectrometry was used to identify and map the untargeted metabolic pathway of F. oxysporum grown using nitrogen limited and organic/inorganic nitrogen supplemented media.</AbstractText><AbstractText Label="RESULTS">Over 1300 metabolites were identified, relating to 42 metabolic pathways. Of these, 520 metabolites merged at pyruvate (glycolysis), succinate (Krebs cycle) and aspartate-glutamate metabolic pathways. CoA depletion at the growth stage triggered the initiation of fatty acid and branched amino acid degradation. This in turn activated propionyl CoA carnitine acetyltransferase enzymes, resulting in nitrogen preservation (urea, putrescine and organic acids end-products). CoA then transferred into the TCA cycle via previously unreported β-alanine and propionyl CoA metabolic pathways, the latter likely being a novel methylmalonyl-CoA mutase activity for F. oxysporum.</AbstractText><AbstractText Label="CONCLUSIONS">The lower supplementation of inorganic nitrogen compounds (≤ 50 mM) and the elimination of nitrates/organic nitrogen sources resulted in TCA autophagy events that boosted mycotoxin-based metabolism and decreased overall F. oxysporum growth. Such knowledge of functional mycotoxin production can be used to supplement agricultural crops and reduce the risk of mycotoxin contamination in human and animal food supplies.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Karpe</LastName><ForeName>A V</ForeName><Initials>AV</Initials><AffiliationInfo><Affiliation>Land & Water, CSIRO, Ecosciences Precinct, Dutton Park, QLD, 4102, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dunn</LastName><ForeName>M S</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>Technical Development, Seqirus, 63 Poplar Road, Parkville, VIC, 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taylor</LastName><ForeName>M C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Land & Water, CSIRO, Acton, ACT, 2601, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nguyen</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Technical Development, Seqirus, 63 Poplar Road, Parkville, VIC, 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ong</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Technical Development, Seqirus, 63 Poplar Road, Parkville, VIC, 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karla</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Technical Development, Seqirus, 63 Poplar Road, Parkville, VIC, 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rockman</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Technical Development, Seqirus, 63 Poplar Road, Parkville, VIC, 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beale</LastName><ForeName>D J</ForeName><Initials>DJ</Initials><Identifier Source="ORCID">0000-0002-9948-9197</Identifier><AffiliationInfo><Affiliation>Land & Water, CSIRO, Ecosciences Precinct, Dutton Park, QLD, 4102, Australia. david.beale@csiro.au.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>12</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Metabolomics</MedlineTA><NlmUniqueID>101274889</NlmUniqueID><ISSNLinking>1573-3882</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009183">Mycotoxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 5.4.99.2</RegistryNumber><NameOfSubstance UI="D008765">Methylmalonyl-CoA Mutase</NameOfSubstance></Chemical><Chemical><RegistryNumber>N762921K75</RegistryNumber><NameOfSubstance UI="D009584">Nitrogen</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D002952" MajorTopicYN="Y">Citric Acid Cycle</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005670" MajorTopicYN="N">Fusarium</DescriptorName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008401" MajorTopicYN="N">Gas Chromatography-Mass Spectrometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053858" MajorTopicYN="N">Metabolic Networks and Pathways</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055442" MajorTopicYN="Y">Metabolome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008765" MajorTopicYN="N">Methylmalonyl-CoA Mutase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009183" MajorTopicYN="N">Mycotoxins</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009584" MajorTopicYN="N">Nitrogen</DescriptorName><QualifierName UI="Q000172" MajorTopicYN="Y">deficiency</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Aspartate</Keyword><Keyword MajorTopicYN="Y">CoA stress</Keyword><Keyword MajorTopicYN="Y">Fusarium mycotoxins</Keyword><Keyword MajorTopicYN="Y">GC-MS</Keyword><Keyword MajorTopicYN="Y">LC-MS</Keyword><Keyword MajorTopicYN="Y">Metabolomics</Keyword><Keyword MajorTopicYN="Y">Nitrogen rescue</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate 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Karla</name><name sortKey="Nguyen, T" sort="Nguyen, T" uniqKey="Nguyen T" first="T" last="Nguyen">T. Nguyen</name><name sortKey="Ong, C" sort="Ong, C" uniqKey="Ong C" first="C" last="Ong">C. Ong</name><name sortKey="Rockman, S" sort="Rockman, S" uniqKey="Rockman S" first="S" last="Rockman">S. Rockman</name><name sortKey="Taylor, M C" sort="Taylor, M C" uniqKey="Taylor M" first="M C" last="Taylor">M C Taylor</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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